Polymer materials in pharmaceutical blister packaging application prospects - blister packaging, polymer materials, pharmaceutical packaging - pharmac
Application in the market share of growing future drugs packaging polymer materials showing the general trend of development: from the container applied to composite packaging materials occupy and dominate the market today use flexible polymer material on drug development very rapidly, with the continual emergence of new materials, understanding of people use the continuous improvement of materials, polymer materials and also will replace old ones, such as the current market, widely used base material flexible PVC blister (PVC), which are amorphous polymers, it is the main characteristics of processing applications is no clear melting point, heated to 120 -150 ~ (2, have a plasticity, thermal stability because of its poor, it must be added alkaline stabilizer to neutralize hydrogen chloride, thus inhibiting its autocatalytic cleavage. Generally speaking PVC chemical resistant, wear-resistant, flame resistant, self-extinguishing, high strength, electrical insulation, barrier, low cost, wide variety of sources and so on. pharmaceutical blister packaging, rigid PVC film is a polyvinyl chloride resin, add some processing aids, by extrusion, rolling and processing methods to produce products that meet the medical requirements, as a substrate for blister packaging , independently of each separate pills, pills and capsules, making it the smallest pharmaceutical packaging unit, the accuracy of drug use, safety is improved significantly, and because the process is simple, low investment, easy processing, so that the system reduce the costs of drug production, the production efficiency is greatly improved from the early application of most pharmaceutical companies now are choosing the material to package tablets, pills and capsules. 90
the 20th century, the original PVC rigid film packaging drugs through performance of its poor water vapor barrier. Therefore not suitable for moisture, steam and other requirements of drug packaging, especially of Chinese medicine pill, powder, granule packing on the water vapor, moisture requirements of more sensitive, packaging materials should be carefully chosen. Other people in the long-term use of PVC during processing and recognize its environment and of human existence the negative effects of organisms, when the PVC monomer will produce vinyl chloride monomer (VCM). In the incineration of PVC products produces dioxins in the process of hydrochloric acid, hydrogen chloride generated from the decomposition of the living environment pollution, its monomer, plasticizer, stabilizer on the human body and will have a serious impact on the environment. In developed countries such as Germany pharmaceutical manufacturers no longer use PVC for blister packs, Japan also limits the production of PVC products, PVC blister packaging materials as replacement will face the choice to use the new polymer packaging materials to protect drug use and safety was imminent.
1 pharmaceutical blister packaging barrier of the polymer material 1.1 PVDC packaging materials (PVDC) Vinylidene chloride homopolymers PVDC as hard to process, even though it has a very outstanding gas barrier properties, but can not it be industrial production, therefore, commonly referred to as PVDC refers to the partial dichloroethene (VDC) copolymer as the main material. In the pharmaceutical packaging applications of PVDC, its content was about 90% VDC, often used with acrylic monomers, acrylic esters. The comonomer played a role in plasticized to improve the processing performance of PVDC, while its barrier properties and no serious cuts. PVDC of the processing industry began in the late 20th century, 30, is first of all by the United States DOW chemical company to achieve industrial production. At that time the "World War II", PVDC is mainly used for military packaging. As the world after the rapid industrial development, PVDC in the pharmaceutical, food shelf life and shelf life extension shows very excellent performance, which for decades PVDC as the barrier material has never been weakened over the leading role, drug packaging materials, excellent function is the choice of barrier properties, PVDC polymer density, regular structure, high crystallinity, and therefore it has excellent gas tightness, excellent moisture resistance, steam capacity, good oil resistance, solvent properties of drugs and. As a result of copolymerization, PVDC can not only co-extruded composite, but also can be blown to other composite materials constitute an excellent barrier properties of composite flexible packaging materials.
1.2 Polyethylene terephthalate
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